Genomic Analysis of Tumors by Array Comparative Genomic Hybridization: More Is Better
نویسندگان
چکیده
منابع مشابه
Genomic analysis of tumors by array comparative genomic hybridization: more is better.
We read with interest the article by Baldwin et al. (1), which describes the use of an array of 32,433 bacterial artificial chromosome clones tiled across the genome (2, 3) to map genomic aberrations in 20 oral squamous cell carcinoma samples by array comparative genomic hybridization (array CGH). The authors conclude that improved detection sensitivity and resolution of tiling arrays is necess...
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Mutations in BRCA1 and BRCA2 account for a significant proportion of hereditary breast cancers. Earlier studies have shown that inherited and sporadic tumors progress along different somatic genetic pathways and that global gene expression profiles distinguish between these groups. To determine whether genomic profiles similarly discriminate among BRCA1, BRCA2, and sporadic tumors, we establish...
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BACKGROUND Male infertility caused by a maturation arrest of spermatogenesis is a condition with an abrupt stop in spermatogenesis, mostly at the level of primary spermatocytes. The etiology remains largely unknown. METHODS We focused on patients with a complete arrest at the spermatocyte level (n = 9) and used array comparative genomic hybridization to screen for deletions or duplications th...
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Although several genes have been investigated in adrenal tumorigenesis, the genetic background of adrenocortical tumors (ACT) remains poorly characterized. In southern Brazil, the annual incidence of ACT is unusually high, ranging from 3.4-4.2/million children, compared with a worldwide incidence of 0.3/million children younger than 15 yr. Environmental factors have been implicated because the ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-05-3611